Recipients

DNA, the genetic material in our cells, is continually attacked by internal and external toxins. Our cells contain enzymes to repair the genetic damage, but these mechanisms can fail. The resulting build-up of mutations over time can lead to cancer – the reason cancer risk rises with age. Audesh Bhat is studying the polymerases (enzymes) responsible for copying and repairing DNA. One enzyme is of particular interest. Polymerase zeta, or pol zeta, is able to copy even heavily-damaged DNA that would stop other polymerases in their tracks. Bhat is investigating how pol zeta works during the process of cell division and repair. He will also study how cells die during mitosis if pol zeta is not present. A better understanding of pol zeta may lead to new therapies or cures for cancer.

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