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An inefficient metabolism contributes to development of metabolic syndrome, a disorder that increases a person’s risk of type 2 diabetes and obesity. Metabolic syndrome appears to be caused in part by improper regulation of an enzyme called AMP-activated protein kinase, or AMPK. Activating this enzyme with prescription drugs or exercise corrects many of the problems associated with the disorder. University of Saskatchewan researcher Dr. Terra Arnason is studying the role of a protein called ubiquitin in regulating yeast AMPK – yeast and human AMPK behave similarly. Better understanding of how the enzyme is regulated and how this control is lost in metabolic syndrome may suggest ways to manipulate the process to improve metabolism in people.

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