Recipients

Atherosclerosis associated cardiovascular disease (CVD) is the leading cause of death in North America. Homocysteine (an amino acid) and hydrogen sulfide (H2S) are both produced naturally through a person’s metabolism. Homocysteine is an independent risk factor for CVD. However, the mechanism of homocysteine in the pathogenesis of atherothrombosis has not been fully understood. Moreover, the potential protective role of H2S in the development of atherosclerosis has never been studied. Dr. Meng’s research will study the role of these two compounds in the development of atherosclerosis and thrombosis using gene knockout mice as a test model. His research will focus specifically on mouse arteries to look for the development and formation of atherosclerotic lesions. Dr. Meng hopes to prove, through this research, that H2S plays an important role in protecting against the development of atherosclerosis and thrombosis.

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