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Alzheimer’s disease (AD) is a progressive, age-related neurodegenerative disease. The number of people afflicted with AD (over age 65) doubles every five years. Two hallmarks of AD are neuro-fibrillary tangles and senile plaques. Neuro-fibrillary tangles are neurofibrils that have become intertwined; senile plaque is a histopathologic lesion of brain tissue. This research will determine whether SSAO deamination (the removal of an amino group from a compound) is involved in the origination and development of AD by using neuro-fibrillary tangles and senile plaques as indicators. A rabbit cholesterol model will be used since rabbits are very vulnerable to atherosclerosis and would clearly show symptoms of AD. An inhibitor will also be used to block any SSAO activity revealing the role of SSAO in AD pathogenesis.

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