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Radiation treatment for brain tumors is limited in humans due to the amount of radiation that healthy brain tissue can tolerate before being damaged. Glutathione is a human substance that assists in the repair of brain tissue from radiation. This project will examine whether reduced glutathione levels in cancerous tumors improve the tumor-killing effects of Microbeam Radiation Therapy (MRT). MRT uses multiple, parallel, high-intensity X-ray beams generated by a synchrotron. Past research has shown that healthy brain tissue has a remarkably high tolerance to these tiny beams as compared to conventional radiation. It is anticipated that this research will help lay groundwork for the use of MRT in humans where other types of cancer treatment are either unsafe or impossible.

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