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Colorectal cancer is one of the leading causes of cancer death in North America. Treatment of advanced cancer remains difficult due to the lack of effective chemotherapy drugs. Therefore, it is important to continue to search for drugs which can slow down or even stop cancer’s progress. One culprit might be N-myristoyltransferase (NMT), an enzyme that modifies a fatty acid. For the first time Dr. Sharma’s laboratory has reported that NMT activity is significantly higher in both animal and human cancerous colon tissue, and higher in gall bladder cancer. With this project, Drs. Ponniah and Sharma are working towards identifying new drugs that might interfere with NMT, and be powerful new weapons against human cancers.

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